1. Signaling Pathways
  2. Epigenetics
  3. Histone Methyltransferase
  4. NSD2/MMSET/WHSC1 Isoform
  5. NSD2/MMSET/WHSC1 Modulator

NSD2/MMSET/WHSC1 Modulator

NSD2/MMSET/WHSC1 Modulator (1):

Cat. No. Product Name Effect Purity
  • HY-179427
    NSD2/H3K36me2 modulator-1
    Modulator
    NSD2/H3K36me2 modulator-1 is an orally active NSD2/H3K36me2 modulator. NSD2/H3K36me2 modulator-1 competitively binds to the SAM pocket of NSD2, potently inhibits NSD2 expression and suppresses H3K36me2 methylation. NSD2/H3K36me2 modulator-1 reverses epithelial-mesenchymal transition (EMT), inhibits cell migration, and induces G0/G1 phase arrest and apoptosis. NSD2/H3K36me2 modulator-1 induces decreased Mitochondrial membrane potential (MMP) and subsequent Reactive oxygen species (ROS) generation. NSD2/H3K36me2 modulator-1 can be used to research the NSD2-targeting epigenetic anticancer strategies for hepatocellular carcinoma (HCC).